Análisis de carbono orgánico total for the laboratory
Total Organic Carbon is an indirect parameter that quantifies the amount of carbon bound to organic compounds present in an aqueous sample. It expresses the overall organic load of the system, which makes it a universal indicator of water quality and an acceptance criterion recognized by the main pharmacopeias (USP <643>, EP 2.2.44, JP and ChP) for purified water and water for injection, as well as in cleaning validation protocols. TOC is determined by photochemical oxidation using 185 nm ultraviolet radiation and persulfates, which convert the organic carbon present in the sample into carbon dioxide. The CO₂ generated dissolves in the aqueous medium to form carbonic acid, whose dissociation produces a proportional change in the conductivity of the solution.
análisis de carbono orgánico total guide
Total organic carbon (TOC) analysis is highly important in the monitoring of purified water (PW) and highly purified water (HPW) systems. It is used in the pharmaceutical, electronics and medical device industries, as well as in water treatment and cleaning validation.
How to choose análisis de carbono orgánico total
- To correctly select the technology to use
- You must consider the estimated concentration range of your sample
- Whether the analysis you require must be sampled online or can be carried out in a laboratory
- And keep the specific application in mind. It is also important to check whether you are following a specific regulation or whether you must comply with a particular standard
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