The triple quadrupole is the standard for targeted quantification of known compounds (bioanalysis, residues, doping) thanks to its sensitivity and robustness; TOF/QTOF provides exact mass and high resolution to identify unknowns and characterize biomolecules. The key question is: quantify the known or discover the unknown?

Modern LC-MS/MS systems routinely quantify at picograms per milliliter in plasma, meeting bioanalytical validation guidelines. The practical limit depends on the matrix, the sample preparation and the chromatographic method.

A site with gases (high-purity nitrogen), extraction, regulated power, temperature control and service space. Installation and qualification are performed by certified personnel — Inolab supports the complete site project in Mexico.

Periodic cleaning of the source, mass calibration, verification with standards and scheduled preventive maintenance. A service contract with local support minimizes unplanned downtime.